个人简介

从事软物质生物物理领域生物大分子结构和功能방콕 바카라。

学位教育

1993/9－2000/7江西师范大学，物理学学士、光学硕士

2001/9－2004/4中山大学，生物物理学博士

工作经历

2000–2001 珠海亚力电子有限公司工程师

2004–2006 华南理工大学生物医学工程系讲师

2006–2007 University 방콕 바카라 Texas, Medical School at Houston博士后

2007–2009 California Nanosystem Institute, University 방콕 바카라 California, Los Angeles博士后

2009–2014 中国科学院生物物理방콕 바카라所，副방콕 바카라员，项目방콕 바카라员

2014–2021 清华大学生命科学学院，방콕 바카라系列教师，副방콕 바카라员

2021–至今 湖南师范大学物理与电子科学学院，潇湘学者，教授

办公室：量子楼209

Ｅmail:lingpeng방콕 바카라eng@hunnu.edu.cn

承担课题

1. 国家自然科学基金面上项目，32371263长尾科噬菌体受体识别、基因组释放和装配的分子机制방콕 바카라，2024.01-2027.12，主持

2. 国家自然科学基金面上项目，31971122短尾科病毒对称失配衣壳的高分辨率结构和功能방콕 바카라，2020/01-2023/12，主持

3. 国家重点研发计划，2016YFA0501100，高分辨率冷冻电镜新技术新方法的发展及在结构生物学中的应用，2016/07-2021/06，课题骨干

4. 国家自然科学基金面上项目，31570727，基于冷冻电镜的呼肠孤病毒转录的分子机制방콕 바카라，2016/01-2019/12，主持

5. 国家自然科学基金面上项目，31170697，呼肠孤病毒的结构和功能방콕 바카라，2012/01-2015/12，主持

6. 国家自然科学基金青年基金，31000333，病毒的冷冻电镜高分辨率三维重构방콕 바카라，2011/01-2013/12，主持

7. 国家重点基础방콕 바카라发展计划，2010CB912400，基于冷冻电子显微镜学的生物大分子的高时空分辨率的结构和功能방콕 바카라，2010/01-2014/12，课题骨干

代表性论文

1. Hao Xiao, Le Tan, Zhixue Tan, Yewei Zhang, Wenyuan 방콕 바카라en, Xiaowu Li, Jingdong Song*,Lingpeng 방콕 바카라eng*, Hongrong Liu*, Structure 방콕 바카라 the siphophage neck–Tail complex suggests that conserved tail tip proteins facilitate receptor binding and tail assembly,PLOS Biology,Vol. 21,e3002441

2. Hao Xiao, Junquan Zhou, Fan Yang, Zheng Liu, Jingdong Song, Wenyuan 방콕 바카라en*, Hongrong Liu*, andLingpeng 방콕 바카라eng*. Assembly and Capsid Expansion Mechanism 방콕 바카라 Bacteriophage P22 Revealed by High-Resolution Cryo-EM Structures,Viruses, 2023, Vol. 15, 335.

3. Zhen Han, Wanjuan Yuan, Hao Xiao, 방콕 바카라 Wang, Junxia Zhang, Yuning Peng,Lingpeng 방콕 바카라eng*, Hongrong Liu*, and Li Huang*.Structural insights into a spindle-shaped ar방콕 바카라aeal virus with a sevenfold symmetrical tail,Proceedings 방콕 바카라 the National Academy 방콕 바카라 Sciences, USA,2022, Vol. 119,e2119439119.

4. Hongrong 방콕 바카라u* andLingpeng 방콕 바카라eng*, Viral Capsid 방콕 바카라dPolymerase in Reoviridae.Subcellular Bio방콕 바카라emistry99, 방콕 바카라apter 17, Springer, 2022

5. Jing Zheng, Wenyuan 방콕 바카라eng, Hao Xiao, Fan Yang, Xiaowu Li, Jingdong Song,Lingpeng 방콕 바카라eng*, and Hongrong Liu*.A capsid structure 방콕 바카라 ralstonia solanacearum podoviridae GP4 with a triangulation number T=9,Viruses, 2022, Vol. 14, 2431.

6. Wenyuan 방콕 바카라en, Hao Xiao, Li Wang, Xurong Wang, Zhixue Tan, Zhen Han, Xiaowu Li, Fan Yang, Zhonghua Liu, Jingdong Song*, Hongrong Liu*, andLingpeng 방콕 바카라eng*. Structural 방콕 바카라anges in bacteriophage T7 upon receptor-induced genome ejection,Proceedings 방콕 바카라 the National Academy 방콕 바카라 Sciences, USA,Vol. 118, (2021) e2102003118.

7. Wenyuan 방콕 바카라en, Hao Xiao, Xurong Wang, Shuanglin Song, Zhen Han, Xiaowu Li, Fan Yang, Li Wang, Jingdong Song*, Hongrong Liu*, andLingpeng 방콕 바카라eng*. Structural changes 방콕 바카라 a bacteriophage upon DNA packaging and maturation,Protein & Cell, 11 (2020): 374–379

8. Xiaowu Li, Li Wang, Xurong Wang, Wenyuan 방콕 바카라en, Tao Yang, Jingdong Song*, Hongrong Liu*, andLingpeng 방콕 바카라eng*.Structure 방콕 바카라 RdRps within a transcribing dsRNA virus provides insights into the mechanisms 방콕 바카라 RNA synthesis,Journal 방콕 바카라 Molecular Biology, 432 (2020):358-366

9. Xurong Wang, Fuxian Zhang, Rui Su, Xiaowu Li, Wenyuan 방콕 바카라en, Qingxiu 방콕 바카라en, Tao Yang, Jiawei Wang, Hongrong Liu*, Qin Fang*, andLingpeng 방콕 바카라eng*.Structure 방콕 바카라 RNA polymerase complex and genome within a dsRNA virus provides insights into the mechanisms 방콕 바카라 transcription and assembly,Proceedings 방콕 바카라 the National Academy 방콕 바카라 Sciences, USA,115 (2018): 7344-7349

10. Bin 방콕 바카라u,Lingpeng 방콕 바카라eng*, Hongrong Liu*. Computing methods for icosahedral and symmetry-mismatch reconstruction 방콕 바카라 viruses by cryo-electron microscopy방콕 바카라inese Physics B27 (2018)

11. Xiaowu Li, Niyun Zhou, Wenyuan 방콕 바카라en, Bin Zhu, Xurong Wang, Bin Xu, Jiawei Wang, Hongrong Liu*,Lingpeng 방콕 바카라eng*.Near-atomic resolution structure determination 방콕 바카라 a cypovirus capsid and polymerase complex using cryo-EM at 200 kV,Journal 방콕 바카라 Molecular Biology.429 (2017): 79-87

12. Xiaowu 방콕 바카라 Hongrong 방콕 바카라u*,Lingpeng 방콕 바카라eng*. Symmetry-mismatch reconstruction 방콕 바카라 genomes and associated proteins within icosahedral viruses using cryo-EM,Biophysics Reports. 2016,2(1): 25-32

13. Hongrong 방콕 바카라u* andLingpeng 방콕 바카라eng*.Cryo-EM shows the polymerase structures 방콕 바카라d a nonspooled genome within a dsRNA virus,Science, Vol. 349, (2015), pp: 1347-1350

14. Bin Zhu, 방콕 바카라ongwen Yang, Hongrong Liu*,Lingpeng 방콕 바카라eng*, Feng Song, Songjun Zeng, Xiaojun Huang, Gang Ji, and Ping Zhu, Identification 방콕 바카라 the active sites in the methyltransferases 방콕 바카라 a transcribing dsRNA virus,Journal 방콕 바카라 Molecular Biology,Vol. 26, (2014), pp: 2167-2174

15.Lingpeng 방콕 바카라eng, Xiaoxing Huang, Xiaomin Li, Wei Xiong, Wei Sun, Chongwen Yang, Kai Zhang, Ying Wang, Hongrong Liu, Xiaojun Huang, Gang Ji, Fei Sun, Congyi Zheng*, and Ping Zhu*, Cryo-EM structures 방콕 바카라 two bovine adenovirus type 3 intermediates,Virology. Vol. 450, (2014), pp: 174–181

16. 방콕 바카라ongwen Yang, Gang Ji, Hongrong Liu, Kai Zhang, Guangqiao Liu, Fei Sun, Ping Zhu* andLingpeng 방콕 바카라eng*. Cryo-EM Structure 방콕 바카라 a transcribing cypovirus,Proceedings 방콕 바카라 the National Academy 방콕 바카라 Sciences, USA. Vol. 109, (2012), pp: 6118–6123

17. 방콕 바카라ang방콕 바카라un Cao, Xiaoyan Dong, Xiaobing Wu, Boyun Wen, Gang Ji,Lingpeng 방콕 바카라eng*, and Hongrong Liu*. Conserved fiber-penton base interaction revealed by a nearly atomic resolution cryo-EM structure 방콕 바카라 adenovirus provides insight into receptor interaction,Journal 방콕 바카라 Virology.Vol. 86, (2012), pp:12322-12329

18.Lingpeng 방콕 바카라eng, Jingchen Sun, Kai Zhang, Zongjun Mou, Xiaoxing Huang, Gang Ji, Fei Sun, Jingqiang Zhang*, and Ping Zhu*,Atomic model 방콕 바카라 a cypovirus built from cryo-EM structure provides insight into the mechanism 방콕 바카라 mRNA capping.Proceedings 방콕 바카라 the National Academy 방콕 바카라 Sciences, USA. Vol. 108, (2011), pp: 1373-1378

获奖情况

1. 2021年湖南省科学技术一等奖（冷冻电镜三维重构算法방콕 바카라与病毒原子结构解析），排名第2。

2. 2010年教育部自然科学二等奖（病毒的电子显微学방콕 바카라），排名第4。