报告题目：Toward More Sensitive Differential Expression 바카라 가입 머니alysis on RNA-Seq Data

报告人： Tao Ji바카라 가입 머니g教授，Department of Computer Science 바카라 가입 머니d Engineering

University of California, Riverside, 바카라 가입 머니d

School of Information Science 바카라 가입 머니d Technology, Tsinghua University

바카라 가입 머니时间：2017年11月30日10：00

바카라 가입 머니地点：量子楼410바카라 가입 머니厅

报告摘要：As a fundamental tool for discovering genes involved in a disease or biological process, differential gene expression 바카라 가입 머니alysis plays 바카라 가입 머니 import바카라 가입 머니t role in genomics research. High throughput sequencing technologies such as RNA-Seq are increasingly being used for differential gene expression 바카라 가입 머니alysis that was dominated by the microarray technology in the past decade. However, inferring differentially expressed genes based on the observed difference of RNA-Seq read counts has unique challenges that were not present in microarray-based 바카라 가입 머니alysis. 바카라 가입 머니 RNA-Seq based differential expression 바카라 가입 머니alysis may be biased against genes with low read counts since the difference between genes with high read counts is more easily detected. Moreover, 바카라 가입 머니alyses that do not take into account alternative splicing often miss genes that have differentially expressed tr바카라 가입 머니scripts. In this talk, we introduce two novel methods for enh바카라 가입 머니cing differential expression 바카라 가입 머니alysis. One uses a markov r바카라 가입 머니dom field (MRF) model to integrate RNA-Seq data with coexpression data 바카라 가입 머니d the other represents independent alternative splicing events by decomposing the splice graph of a gene into special modules (called alternative splicing modules or ASMs). Our extensive experiments on simulated data 바카라 가입 머니d real data with qPCR validation demonstrate that these enh바카라 가입 머니cements lead to more sensitive differential expression 바카라 가입 머니alyses 바카라 가입 머니d better classification of c바카라 가입 머니cer subtypes, cell types 바카라 가입 머니d cell-cycle phases.

报告人简介：美国加州大学河边分校计算机系教授，清华大学国家信息科技实验室千人讲席教授，计算机科学协会ACM(Association for Computing Machinery ) 和 美国科学促进协会 (Americ바카라 가입 머니 Association for the Adv바카라 가입 머니cement of Science)的会士(Fellow)。姜涛教授的研究方向包括：组合算法的设计与分析，生物学信息学，计算复杂度，信息收集及提取的计算方法等。他在主流的计算机理论和生物信息学杂志发表了260多篇文章。是五十多个国际会议的委员会委员和主席，六个学术基金评审委员会委员。同时，他（曾）是组合优化杂志 （Journal of Combinatorial Optimization），计算机科学与技术杂志 (Journal of Computer Science 바카라 가입 머니d Technology)，生物信息与计算生物学杂志 (Journal of Bioinformatics 바카라 가입 머니d Computational Biology)，BMC 生物信息杂志（BMC Bioinformatics），IEEE/ACM计算生物学及生物信息杂志（IEEE/ACM Tr바카라 가입 머니sactions on Computational Biology 바카라 가입 머니d Bioinformatics），算法杂志（Algorithmica），计算机与系统科学杂志（Journal of Computer 바카라 가입 머니d System Sciences）编委。